Varicella-Zoster virus ORF9 Is an antagonist of the DNA sensor cGAS

Varicella-Zoster virus (VZV) causes chickenpox and shingles. Although infection is associated with severe morbidity in some individuals, the molecular mechanisms that determine innate immune responses remain poorly defined. We found that the cGAS/STING DNA sensing pathway was critically required for...

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Bibliographic Details
Main Authors: Hertzog, J, Rigby, RE, Roll, S, Cursi, C, Chauveau, L, Davenne, T, Rehwinkel, J
Format: Journal article
Language:English
Published: Cold Spring Harbor Laboratory 2020