Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.

Bibliographic Details
Main Authors: Heightman, T, Scott, J, Longley, M, Bordas, V, Dean, D, Elliott, R, Hutley, G, Witherington, J, Abberley, L, Passingham, B, Berlanga, M, de Los Frailes, M, Wise, A, Powney, B, Muir, A, McKay, F, Butler, S, Winborn, K, Gardner, C, Darton, J, Campbell, C, Sanger, G
Format: Journal article
Language:English
Published: 2007