Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.
High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797095838082662400 |
|---|---|
| author | Heightman, T Scott, J Longley, M Bordas, V Dean, D Elliott, R Hutley, G Witherington, J Abberley, L Passingham, B Berlanga, M de Los Frailes, M Wise, A Powney, B Muir, A McKay, F Butler, S Winborn, K Gardner, C Darton, J Campbell, C Sanger, G |
| author_facet | Heightman, T Scott, J Longley, M Bordas, V Dean, D Elliott, R Hutley, G Witherington, J Abberley, L Passingham, B Berlanga, M de Los Frailes, M Wise, A Powney, B Muir, A McKay, F Butler, S Winborn, K Gardner, C Darton, J Campbell, C Sanger, G |
| author_sort | Heightman, T |
| collection | OXFORD |
| description | High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats. |
| first_indexed | 2024-03-07T04:33:40Z |
| format | Journal article |
| id | oxford-uuid:cf301f77-8152-4a9c-a332-627b1b89e611 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:40Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:cf301f77-8152-4a9c-a332-627b1b89e6112022-03-27T07:40:56ZPotent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf301f77-8152-4a9c-a332-627b1b89e611EnglishSymplectic Elements at Oxford2007Heightman, TScott, JLongley, MBordas, VDean, DElliott, RHutley, GWitherington, JAbberley, LPassingham, BBerlanga, Mde Los Frailes, MWise, APowney, BMuir, AMcKay, FButler, SWinborn, KGardner, CDarton, JCampbell, CSanger, GHigh throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats. |
| spellingShingle | Heightman, T Scott, J Longley, M Bordas, V Dean, D Elliott, R Hutley, G Witherington, J Abberley, L Passingham, B Berlanga, M de Los Frailes, M Wise, A Powney, B Muir, A McKay, F Butler, S Winborn, K Gardner, C Darton, J Campbell, C Sanger, G Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. |
| title | Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. |
| title_full | Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. |
| title_fullStr | Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. |
| title_full_unstemmed | Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. |
| title_short | Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. |
| title_sort | potent achiral agonists of the ghrelin growth hormone secretagogue receptor part i lead identification |
| work_keys_str_mv | AT heightmant potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT scottj potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT longleym potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT bordasv potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT deand potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT elliottr potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT hutleyg potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT witheringtonj potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT abberleyl potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT passinghamb potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT berlangam potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT delosfrailesm potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT wisea potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT powneyb potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT muira potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT mckayf potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT butlers potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT winbornk potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT gardnerc potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT dartonj potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT campbellc potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification AT sangerg potentachiralagonistsoftheghrelingrowthhormonesecretagoguereceptorpartileadidentification |