pH and proton sensor GPR65 determine susceptibility to atopic dermatitis

pH and proton sensor GPR65 determine susceptibility to atopic dermatitis

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduces GPR65 signaling, showed a significa...

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Bibliographic Details
Main Authors: Xie, L, McKenzie, CI, Qu, X, Mu, Y, Wang, Q, Bing, N, Naidoo, K, Alam, MJ, Yu, D, Gong, F, Ang, C, Robert, R, Marques, FZ, Furlotte, N, Hinds, D, Gasser, O, Xavier, RJ, MacKay, CR, Agee, M, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Huber, KE, Kleinman, A, Litterman, NK, McCreight, JC, McIntyre, MH, Mountain, JL, Noblin, ES, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Tung, JY, Vacic, V
Format: Journal article
Language:English
Published: The American Association of Immunologists 2021

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