Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses
Antibody affnity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHC II) proteins. How GC B cells are able...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Published: |
Rockefeller University Press
2016
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