The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here, we defined the molecular and cellular mechanisms of this inflammation-mediated tissue priming. Re-exposure to inflammatory sti...

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Bibliographic Details
Main Authors: Friščić, J, Böttcher, M, Reinwald, C, Bruns, H, Wirth, B, Popp, S-J, Walker, KI, Ackermann, JA, Chen, X, Turner, J, Zhu, H, Seyler, L, Euler, M, Kirchner, P, Krüger, R, Ekici, AB, Major, T, Aust, O, Wiedner, D, Fischer, A, Andes, FT, Stanojevic, Z, Trajkovic, V, Herrmann, M, Korb-Pap, A, Wank, I, Hess, A, Winter, J, Wixler, V, Distler, J, Steiner, G, Kiener, HP, Frey, B, Kling, L, Raza, K, Frey, S, Kleyer, A, Bäuerle, T, Hughes, TR, Grüneboom, A, Steffen, U, Krönke, G, Croft, AP, Filer, A, Köhl, J, Klein, K, Buckley, CD, Schett, G, Mougiakakos, D, Hoffmann, MH
Format: Journal article
Language:English
Published: Cell Press 2021

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