XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.
XRCC1 is a scaffold protein that interacts with several DNA repair proteins and plays a critical role in DNA base excision repair (BER). XRCC1 protein is in a tight complex with DNA ligase IIIalpha (Lig III) and this complex is involved in the ligation step of both BER and repair of DNA single stran...
Główni autorzy: | Parsons, J, Dianova, I, Finch, D, Tait, P, Ström, C, Helleday, T, Dianov, G |
---|---|
Format: | Journal article |
Język: | English |
Wydane: |
2010
|
Podobne zapisy
-
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.
od: Ström, C, i wsp.
Wydane: (2011) -
XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
od: Dianova, I, i wsp.
Wydane: (2004) -
DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
od: Parsons, J, i wsp.
Wydane: (2005) -
CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
od: Parsons, J, i wsp.
Wydane: (2008) -
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
od: Meisenberg, C, i wsp.
Wydane: (2012)