Catalytic and Anticatalytic snapshots of a short-form ATP Phosphoribosyltransferase
Allosteric modulation of catalysis is a common regulatory strategy of flux-controlling biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyses the first reaction in histidine biosynthesis, the magnesium-dependent condensation of ATP and 5-phospho-β-D-ribosyl-1-pyrophosphate...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
American Chemical Society
2018
|