Induction of immunity and tolerance in vitro by hapten protein conjugates. 3. Hapten inhibition studies of antigen binding to B cells in immunity and tolerance.

The capacity of dissociated spleen cell suspensions to be immunized by dinitrophenylated polymeric flagellin (DNP POL), in the absence of thymus-dependent lymphocytes or macrophages, provided a simple experimental system to investigate the mechanism of binding of antigen molecules to nonthymus-depen...