Regulation of mRNA levels by decay-promoting introns that recruit the exosome specificity factor Mmi1
In eukaryotic cells, inefficient splicing is surprisingly common and leads to degradation of transcripts with retained introns. How pre-mRNAs are committed to nuclear decay is unknown. Here we uncover a mechanism by which specific intron-containing transcripts are targeted for nuclear degradation in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2015
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