Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions

A person’s lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipo...

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Main Authors: de Vries, PS, Watkins, H, Brown, MR, Bentley, AR, Sung, YJ, Winkler, TW, Ntalla, I, Schwander, K, Kraja, AT, Guo, X, InterAct Consortium, Franceschini, N, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Aschard, H, Bartz, TM, Bielak, LF, Deng, X, Dorajoo, R, Lohman, KK, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Evangelou, E, Graff, M, Alver, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Gandin, I, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Jackson, AU, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Lee, JH, Luan, J, Lyytikäinen, L-P, Matoba, N, Nolte, IM, Pietzner, M, Riaz, M, Said, MA, Scott, RA, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, BO, van der Most, PJ, Varga, TV, Wang, Y, Ware, EB, Wen, W, Yanek, LR, Zhang, W, Zhao, JH, Afaq, S, Amin, N, Amini, M, Arking, DE, Aung, T, Ballantyne, C, Boerwinkle, E, Broeckel, U, Campbell, A, Canouil, M, Charumathi, S, Chen, Y-DI, Connell, JM, de Faire, U, de Las Fuentes, L, de Mutsert, R, de Silva, HJ, Ding, J, Dominiczak, AF, Duan, Q, Eaton, CB, Eppinga, RN, Faul, JD, Fisher, V, Forrester, T, Franco, OH, Friedlander, Y, Ghanbari, M, Giulianini, F, Grabe, HJ, Grove, ML, Gu, CC, Harris, TB, Heikkinen, S, Heng, C-K, Hirata, M, Hixson, JE, Howard, BV, Ikram, MA, Jacobs, DR, Johnson, C, Jonas, JB, Kammerer, CM, Katsuya, T, Khor, CC, Kilpeläinen, TO, Koh, W-P, Koistinen, HA, Kolcic, I, Kooperberg, C, Krieger, JE, Kritchevsky, SB, Kubo, M, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lemaitre, RN, Li, Y, Liang, J, Liu, J, Liu, K, Loh, M, Louie, T, Mägi, R, Manichaikul, AW, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, KL, Mosley, TH, Mukamal, KJ, Nalls, MA, Nauck, M, Nelson, CP, Sotoodehnia, N, O'Connell, JR, Palmer, ND, Pazoki, R, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Poulter, N, Raffel, LJ, Raitakari, OT, Reiner, AP, Rice, TK, Rich, SS, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Shi, Y, Sidney, S, Sims, M, Smith, BH, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tan, N, Taylor, KD, Teo, YY, Tham, YC, Uitterlinden, AG, van Heemst, D, Vuckovic, D, Waldenberger, M, Wang, L, Wang, Z, Wei, WB, Williams, C, Wilson, G, Wojczynski, MK, Yao, J, Yu, B, Yu, C, Yuan, J-M, Zhao, W, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Deary, IJ, Esko, T, Farrall, M, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Kamatani, Y, Kato, N, Kooner, JS, Laakso, M, Leander, K, Lehtimäki, T, Magnusson, PKE, Penninx, B, Pereira, AC, Rauramaa, R, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wang, YX, Wareham, NJ, Weir, DR, Wickremasinghe, AR, Zheng, W, Elliott, P, North, KE, Bouchard, C, Evans, MK, Gudnason, V, Liu, C-T, Liu, Y, Psaty, BM, Ridker, PM, van Dam, RM, Kardia, SLR, Zhu, X, Rotimi, CN, Mook-Kanamori, DO, Fornage, M, Kelly, TN, Fox, ER, Hayward, C, van Duijn, CM, Tai, ES, Wong, TY, Rotter, JI, Gauderman, WJ, Province, MA, Munroe, PB, Rice, K, Chasman, DI, Cupples, LA, Rao, DC, Morrison, AC
Andre forfattere: Lifelines Cohort, Groningen, The Netherlands (Lifelines Cohort Study)
Format: Journal article
Sprog:English
Udgivet: Oxford University Press 2019