A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.

MOTIVATION: Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and/or associated with disease, and may have utility in trans-ethnic mapping studies. RESULTS: We present a novel pseudo Bayes factor (PBF) approach that asses...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Clark, T, Campino, S, Anastasi, E, Auburn, S, Teo, Y, Small, K, Rockett, K, Kwiatkowski, D, Holmes, C
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: 2010