Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.

Defects in mitochondrial enzymes predispose to severe developmental defects as well as tumorigenesis. Heterozygous germline mutations in the nuclear gene encoding fumarate hydratase (FH), an enzyme catalyzing the hydration of fumarate in the Krebs tricarboxylic acid cycle, cause hereditary leiomyoma...

詳細記述

書誌詳細
主要な著者: Vanharanta, S, Pollard, P, Lehtonen, H, Laiho, P, Sjöberg, J, Leminen, A, Aittomäki, K, Arola, J, Kruhoffer, M, Orntoft, T, Tomlinson, I, Kiuru, M, Arango, D, Aaltonen, L
フォーマット: Journal article
言語:English
出版事項: 2006