Microhomologies are prevalent at Cas9-induced larger deletions

Microhomologies are prevalent at Cas9-induced larger deletions

<p>The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9<sup>D10A</sup> nickases or paired Cas9 nuclease we characterize unintended larger deletions at on-target sites that frequently evade common genotyping practices. We fo...

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Manylion Llyfryddiaeth
Prif Awduron: Owens, D, Caulder, A, Frontera, V, Harman, J, Allan, A, Bucakci, A, Greder, L, Codner, G, Hublitz, P, McHugh, P, Teboul, L, De Bruijn, M
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Oxford University Press 2019

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