Microhomologies are prevalent at Cas9-induced larger deletions
<p>The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9<sup>D10A</sup> nickases or paired Cas9 nuclease we characterize unintended larger deletions at on-target sites that frequently evade common genotyping practices. We fo...
| المؤلفون الرئيسيون: | , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Oxford University Press
2019
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