Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca2+-mobilizing messengers important for modulating cardiac excitation–contraction coupling and pathophysiology. CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both NAADP and cADPR...

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Main Authors: Lin, W, Bolton, E, Cortopassi, W, Wang, Y, O'Brien, F, Maciejewska, M, Jacobson, M, Garnham, C, Ruas, M, Parrington, J, Lei, M, Sitsapesan, R, Galione, A, Terrar, D
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology Onli 2017