Regulation of receptor tyrosine kinase ligand processing.

A primary mode of regulating receptor tyrosine kinase (RTK) signaling is to control access of ligand to its receptor. Many RTK ligands are synthesized as transmembrane proteins. Frequently, the active ligand must be released from the membrane by proteolysis before signaling can occur. Here, we discu...

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Bibliographic Details
Main Authors: Adrain, C, Freeman, M
Format: Journal article
Language:English
Published: 2014