Structural determinants of conformationally selective, prion-binding aptamers.

We have recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind selectively to disease-associated beta-sheet-rich forms of the prion protein, PrP, from a number of mammalian species. These aptamers inhibit the accumulation of protease-resistant forms of PrP in...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Sayer, N, Cubin, M, Rhie, A, Bullock, M, Tahiri-Alaoui, A, James, W
פורמט: Journal article
שפה:English
יצא לאור: 2004