Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of β-lactam ring containing natural products. IPNS catalyses formation of the bicyclic penicillin nucleus from a tripeptide. 2OG oxygenases catalyse reactions t...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2018
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