α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP. β-Amyloid levels and APP amyloidogenic processing were investigated in neuronal cell lines stably overexpre...

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Bibliographic Details
Main Authors: Roberts, HL, Schneider, BL, Brown, DR
Format: Journal article
Language:English
Published: Public Library of Science 2017