α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP. β-Amyloid levels and APP amyloidogenic processing were investigated in neuronal cell lines stably overexpre...
Main Authors: | , , |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2017
|