Proximity ligation assay for detection of R-Loop complexes upon DNA damage

In situ Proximity Ligation Assay (PLA ) can be used to detect the close proximity (less than ~40 nm) of two biological molecules of interest in cells. Here we report the application of this method for the specific detection of R-loop interacting proteins and RNA modifications in close proximity to R...

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Bibliographic Details
Main Authors: Alagia, A, Ketley, RF, Gullerova, M
Format: Journal article
Language:English
Published: Springer 2022