IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.

OBJECTIVE: Interleukin-6 (IL-6) is a pro-inflammatory cytokine which is a prognostic marker associated with left ventricular contractile dysfunction and heart failure. On the other hand, IL-6 activates signalling pathways which mediate delayed ischemic preconditioning. We have therefore studied the...

Full description

Bibliographic Details
Main Authors: Smart, N, Mojet, M, Latchman, D, Marber, MS, Duchen, MR, Heads, R
Format: Journal article
Language:English
Published: 2006