Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes. A key finding of our study is the identification of mutations...

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Bibliographic Details
Main Authors:	Behjati, S, Tarpey, PS, Haase, K, Ye, H, Young, MD, Alexandrov, LB, Farndon, SJ, Collord, G, Wedge, DC, Martincorena, I, Cooke, SL, Davies, H, Mifsud, W, Lidgren, M, Martin, S, Latimer, C, Maddison, M, Butler, AP, Teague, JW, Pillay, N, Shlien, A, McDermott, U, Futreal, PA, Baumhoer, D, Zaikova, O, Bjerkehagen, B, Myklebost, O, Amary, MF, Tirabosco, R, Van Loo, P, Stratton, MR, Flanagan, AM, Campbell, PJ
Format:	Journal article
Language:	English
Published:	Nature Communications 2017

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

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