A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breas...

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Main Authors: Coviello, A, Haring, R, Wellons, M, Vaidya, D, Lehtimäki, T, Keildson, S, Lunetta, K, He, C, Fornage, M, Lagou, V, Mangino, M, Onland-Moret, N, Chen, B, Eriksson, J, Garcia, M, Liu, Y, Koster, A, Lohman, K, Lyytikäinen, L, Petersen, A, Prescott, J, Stolk, L, Vandenput, L, Wood, A, Zhuang, W, Ruokonen, A, Hartikainen, A, Pouta, A, Bandinelli, S, Biffar, R, Brabant, G, Cox, D, Chen, Y, Cummings, S, Ferrucci, L, Gunter, M, Hankinson, SE, Martikainen, H, Hofman, A, Homuth, G, Illig, T, Jansson, J, Johnson, A, Karasik, D, Karlsson, M, Kettunen, J, Kiel, D, Kraft, P, Liu, J, Ljunggren, Ö, Lorentzon, M, Maggio, M, Markus, MR, Mellström, D, Miljkovic, I, Mirel, D, Nelson, S, Morin Papunen, L, Peeters, P, Prokopenko, I, Raffel, L, Reincke, M, Reiner, A, Rexrode, K, Rivadeneira, F, Schwartz, S, Siscovick, D, Soranzo, N, Stöckl, D, Tworoger, S, Uitterlinden, A, Gils, v, Vasan, R, Wichmann, H, Zhai, G, Bhasin, S, Bidlingmaier, M, Chanock, S, De Vivo, I, Harris, T, Hunter, D, Kähönen, M, Liu, S, Ouyang, P, Spector, T, van der Schouw, Y, Viikari, J, Wallaschofski, H, McCarthy, M, Frayling, T, Murray, A, Franks, S, Järvelin, MR, de Jong, F, Raitakari, O, Teumer, A, Ohlsson, C, Murabito, J, Perry, JR
Format: Journal article
Language:English
Published: Public Library of Science 2012

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