An integrated taxonomy for monogenic inflammatory bowel disease

An integrated taxonomy for monogenic inflammatory bowel disease

Background and aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the essential roles of individual genes in pathways and networks safeguarding immune tolerance and gut homeostasis. Methods To build a taxonomy model we assessed 165 disorders. Genes were prioritized based on penetran...

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Main Authors: Bolton, C, Smillie, CS, Pandey, S, Elmentaite, R, Wei, G, Argmann, C, Aschenbrenner, D, James, KR, McGovern, DPB, Macchi, M, Cho, J, Shouval, DS, Kammermeier, J, Koletzko, S, Bagalopal, K, Capitani, M, Cavounidis, A, Pires, E, Weidinger, C, McCullagh, J, Arkwright, PD, Haller, W, Siegmund, B, Peters, L, Jostins, L, Travis, SPL, Anderson, CA, Snapper, S, Klein, C, Schadt, E, Zilbauer, M, Xavier, R, Teichmann, S, Muise, AM, Regev, A, Uhlig, HH
Format: Journal article
Language:English
Published: Elsevier 2021

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