Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.

Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.

The LIM-only family of proteins comprises four members; two of these (LMO1 and LMO2) are involved in human T-cell leukemia via chromosomal translocations, and LMO2 is a master regulator of hematopoiesis. We have carried out gene targeting of the other members of the LIM-only family, viz., genes Lmo1...

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Bibliographic Details
Main Authors: Tse, E, Smith, A, Hunt, S, Lavenir, I, Forster, A, Warren, A, Grutz, G, Foroni, L, Carlton, M, Colledge, W, Boehm, T, Rabbitts, T
Format: Journal article
Language:English
Published: 2004

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