CHARIOT: Our first dose escalation trial using the time to event continual reassessment method – design, difficulties, delivery

CHARIOT is a single-arm open-label, phase I dose escalation trial and is the first trial examining the combination of radiotherapy, chemotherapy, and the ataxia telangiectasia mutated Rad3-related (ATR) inhibitor M6620 in patients with oesophageal cancer. The aim is to identify the maximum tolerated...

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Bibliographic Details
Main Authors: Frangou, E, Holmes, J, Love, S, Hawkins, M
Format: Conference item
Published: University of Cambridge 2018