Crystal structure of a human GABAA receptor

Type-A γ-aminobutyric acid receptors (GABAA Rs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAA R signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy. Here we present the first three-dimensional st...

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Bibliografische gegevens
Hoofdauteurs: Miller, P, Aricescu, A
Formaat: Journal article
Taal:English
Gepubliceerd in: Nature Publishing Group 2014