The structural basis of the inhibition of human glycosidases by castanospermine analogues.

The structural basis of the inhibition of human glycosidases by castanospermine analogues.

A series of epimers and deoxy derivatives of castanospermine has been synthesized to investigate the contribution of the different chiral centres to the specificity and potency of inhibition of human liver glycosidases. Castanospermine inhibits all forms of alpha- and beta-D-glucosidases, but altera...

書誌詳細
主要な著者:	Winchester, BG, Cenci di Bello, I, Richardson, A, Nash, R, Fellows, L, Ramsden, N, Fleet, G
フォーマット:	Journal article
言語:	English
出版事項:	1990

類似資料

The structural basis of the inhibition of human alpha-mannosidases by azafuranose analogues of mannose.
著者:: Winchester, B, 等
出版事項: (1993)

Plagiarizing plants: amino sugars as a class of glycosidase inhibitors.
著者:: Fleet, G, 等
出版事項: (1990)

PLAGIARIZING PLANTS - AMINO-SUGARS AS A CLASS OF GLYCOSIDASE INHIBITORS
著者:: Fleet, G, 等
出版事項: (1990)

PLAGIARIZING PLANTS - AMINO-SUGARS AS A CLASS OF GLYCOSIDASE INHIBITORS
著者:: Fleet, G, 等
出版事項: (1990)

GLYCOSIDASE INHIBITION BY PLANT ALKALOIDS WHICH ARE STRUCTURAL ANALOGS OF MONOSACCHARIDES
著者:: Evans, S, 等
出版事項: (1985)

Synthesis and glycosidase inhibition of broussonetine M and its analogues
著者:: Wu, Q, 等
出版事項: (2019)

Synthesis and Glycosidase Inhibition of Broussonetine M and Its Analogues
著者:: Qing-Kun Wu, 等
出版事項: (2019-10-01)

Change in specificity of glycosidase inhibition by N-alkylation of amino sugars.
著者:: al Daher, S, 等
出版事項: (1989)

Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
著者:: Asano, N, 等
出版事項: (1998)

Amino-sugar glycosidase inhibitors: versatile tools for glycobiologists.
著者:: Winchester, B, 等
出版事項: (1992)

SYNTHESIS AND EFFECTS ON HUMAN LIVER GLYCOSIDASES OF 6-DEOXY-DMDP
著者:: Hughes, D, 等
出版事項: (1993)

Chapter 13 Alkaloidal Glycosidase Inhibitors from Plants
著者:: Fellows, L, 等
出版事項: (1989)

New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.
著者:: Ghada Allan, 等
出版事項: (2013-01-01)

SYNTHESIS AND EFFECTS ON HUMAN LIVER GLYCOSIDASES OF SOME 6-DEOXYDMDP ANALOGS
著者:: Beacham, A, 等
出版事項: (1994)

IMINOHEPTITOLS AS GLYCOSIDASE INHIBITORS - SYNTHESIS OF, AND MANNOSIDASE AND FUCOSIDASE INHIBITION BY, ALPHA-HOMOMANNOJIRMYCIN AND 6-EPI-HOMOMANNOJIRMYCIN
著者:: Bruce, I, 等
出版事項: (1989)

Effect on human liver glycosidases and short syntheses of 1 alpha,2 alpha,6 alpha,7 alpha,7a beta-1,2,6,7-tetrahydroxypyrrolizidine from D-glycero-D-gulo-heptono-1,4-lactone.
著者:: Collin, W, 等
出版事項: (1990)

AN ALTERNATIVE PROPOSAL FOR THE MODE OF INHIBITION OF GLYCOSIDASE ACTIVITY BY POLYHYDROXYLATED PIPERIDINES, PYRROLIDINES AND INDOLIZIDINES - IMPLICATIONS FOR THE MECHANISM OF ACTION OF SOME GLYCOSIDASES
著者:: Fleet, G
出版事項: (1985)

TETRAZOLES OF MANNO-PYRANOSES AND RHAMNO-PYRANOSES - INHIBITION OF GLYCOSIDASES BY TETRAZOLES AND OTHER MANNOSE MIMICS
著者:: Brandstetter, T, 等
出版事項: (1995)

Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine
著者:: Van Ameijde, J, 等
出版事項: (2006)

MANIPULATION OF THE OLIGOSACCHARIDE COMPOSITION OF INFLUENZA-VIRUS AND SINDBIS VIRUS GLYCOPROTEINS WITH GLYCOSIDASE INHIBITORS
著者:: Mcdowell, W, 等
出版事項: (1989)

Isolation of glycosidase-inhibiting hyacinthacines and related alkaloids from Scilla socialis.
著者:: Kato, A, 等
出版事項: (2007)

Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta
著者:: Watson, A, 等
出版事項: (1997)

Use of castanospermine and substituted-castonospermine compounds for treating hepatitis virus infections
著者:: Jacob, G, 等
出版事項: (2001)

IMINOHEPTITOLS AS GLYCOSIDASE INHIBITORS - SYNTHESIS OF AND SPECIFIC ALPHA-L-FUCOSIDASE INHIBITION BY BETA-L-HOMOFUCONOJIRIMYCIN AND 1-BETA-C-SUBSTITUTED DEOXYMANNOJIRIMYCINS
著者:: Fleet, G, 等
出版事項: (1989)

Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition
著者:: Zhao, H, 等
出版事項: (2013)

SYNTHESIS OF POLYHYDROXYLATED AMINO-COMPOUNDS AS GLYCOSIDASE INHIBITORS
著者:: Fleet, G
出版事項: (1988)

SYNTHESIS OF AMINOSUGAR GLYCOSIDASE INHIBITORS FROM PLANTS
著者:: Fleet, G
出版事項: (1991)

IMINOHEPTITOLS AS GLYCOSIDASE INHIBITORS - SYNTHESIS OF ALPHA-HOMOMANNOJIRIMYCIN, 6-EPI-ALPHA-HOMOMANNOJIRIMYCIN AND OF A HIGHLY SUBSTITUTED PIPECOLIC ACID
著者:: Bruce, I, 等
出版事項: (1992)

L-DMDP, L-homoDMDP and their C-3 fluorinated derivatives: synthesis and glycosidase-inhibition.
著者:: Li, Y, 等
出版事項: (2011)

Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from D- and L-gulonolactone.
著者:: Fleet, G, 等
出版事項: (1990)

SYNTHESIS OF POLYHYDROXYLATED PYRROLIDINES, PIPERIDINES, AND OCTAHYDROINDOLIZINES AS GLYCOSIDASE INHIBITORS
著者:: Fleet, G
出版事項: (1989)

Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application
著者:: Asano, N, 等
出版事項: (2000)

Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid.
著者:: Hu, X, 等
出版事項: (2010)

Vinylogous Mukaiyama aldol reactions with 4-oxy-2-trimethylsilyloxypyrroles: relevance to castanospermine synthesis
著者:: Roger Hunter, 等
出版事項: (2007-11-01)

First total synthesis of (+)-broussonetine W: Glycosidase inhibition of natural product andamp; analogs
著者:: Song, Y, 等
出版事項: (2017)

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure.
著者:: Eva Ramos-Morales, 等
出版事項: (2017-01-01)

Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine.
著者:: H Masuno, 等
出版事項: (1992-09-01)

DELTA-LACTAMS - SYNTHESIS FROM D-GLUCOSE, AND PRELIMINARY EVALUATION AS A FUCOSIDASE INHIBITOR, OF L-FUCONIC-DELTA-LACTAM
著者:: Fleet, G, 等
出版事項: (1988)

Gas-phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl deoxynojirimycin
著者:: Jockusch, R, 等
出版事項: (2004)

SYNTHESIS FROM A HEPTONOLACTONE AND EFFECT ON GLYCOSIDASES OF (1S,2R,6R,7S)-1,2,6,7-TETRAHYDROXYPYRROLIZIDINE
著者:: Fairbanks, A, 等
出版事項: (1991)