Pharmacological characterization of the putative cADP-ribose receptor.

cADP-ribose (cADPR), a naturally occurring metabolite of NAD(+), has been shown to be an important regulator of intracellular Ca(2+) release. Considerable evidence suggests that cADPR is the endogenous modulator of the ryanodine receptor (RyR), which mediates Ca(2+)-induced Ca(2+) release (CICR). In...

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Bibliographic Details
Main Authors: Thomas, J, Masgrau, R, Churchill, G, Galione, A
Format: Journal article
Language:English
Published: 2001