A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response...

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Những tác giả chính: Powrie, F, Carlino, J, Leach, M, Mauze, S, Coffman, R
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1996