A rapid-response humoral vaccine platform exploiting pre-existing non-cognate populations of anti-vaccine or anti-viral CD4+ T helper cells to confirm B cell activation

The need for CD4+ T cell responses to arise de novo following vaccination can limit the speed of B cell responses. Populations of pre-existing vaccine-induced or anti-viral CD4+ T cells recognising distinct antigens could be exploited to overcome this limitation. We hypothesise that liposomal vaccin...

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Bibliographic Details
Main Authors: Hills, T, Jakeman, P, Carlisle, R, Klenerman, P, Seymour, L, Cawood, R
Format: Journal article
Language:English
Published: Public Library of Science 2016