From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxy...
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Detalhes bibliográficos
| Autor principal: |
Ratcliffe, P |
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| Formato: | Conference item
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| Publicado em: |
2002
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