From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxy...
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| Format: | Conference item |
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2002
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| _version_ | 1797096293617631232 |
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| author | Ratcliffe, P |
| author_facet | Ratcliffe, P |
| author_sort | Ratcliffe, P |
| collection | OXFORD |
| description | The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the alpha subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal. |
| first_indexed | 2024-03-07T04:39:49Z |
| format | Conference item |
| id | oxford-uuid:d13a0cc9-9d49-4d3b-86c6-d36dd17c22fc |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:39:49Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:d13a0cc9-9d49-4d3b-86c6-d36dd17c22fc2022-03-27T07:55:37ZFrom erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:d13a0cc9-9d49-4d3b-86c6-d36dd17c22fcSymplectic Elements at Oxford2002Ratcliffe, PThe regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the alpha subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal. |
| spellingShingle | Ratcliffe, P From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |
| title | From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |
| title_full | From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |
| title_fullStr | From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |
| title_full_unstemmed | From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |
| title_short | From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |
| title_sort | from erythropoietin to oxygen hypoxia inducible factor hydroxylases and the hypoxia signal pathway |
| work_keys_str_mv | AT ratcliffep fromerythropoietintooxygenhypoxiainduciblefactorhydroxylasesandthehypoxiasignalpathway |