Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers.
Polymerases ε and δ are the main enzymes that replicate eukaryotic DNA. Accurate replication occurs through Watson-Crick base pairing and also through the action of the polymerases' exonuclease (proofreading) domains. We have recently shown that germline exonuclease domain mutations (EDMs) of P...
Main Authors: | , |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2013
|