Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers.
Polymerases ε and δ are the main enzymes that replicate eukaryotic DNA. Accurate replication occurs through Watson-Crick base pairing and also through the action of the polymerases' exonuclease (proofreading) domains. We have recently shown that germline exonuclease domain mutations (EDMs) of P...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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