Development and validation of an 'in silico' decision-tool to guide optimisation of intravenous artesunate dosing regimens for severe falciparum malaria patients

Most deaths from severe falciparum malaria occur within 24 hours of presentation to hospital. Intravenous (i.v.) artesunate is the first-line treatment for severe falciparum malaria, but its efficacy may be compromised by delayed parasitological responses. In patients with severe malaria the life-sa...

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Bibliographic Details
Main Authors: Zaloumis, SG, Whyte, JM, Tarning, J, Krishna, S, McCaw, JM, Cao, P, White, MT, Dini, S, Fowkes, FJI, Maude, RJ, Kremsner, P, Dondorp, A, Price, RN, White, NJ, Simpson, JA
Format: Journal article
Language:English
Published: American Society for Microbiology 2021