Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not completely understood. Here we show that heterozygous Vps34 kinase-dead mice...

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Bibliographic Details
Main Authors:	Bilanges, B, Alliouachene, S, Pearce, W, Morelli, D, Szabadkai, G, Chung, Y-L, Chicanne, G, Valet, C, Hill, JM, Voshol, PJ, Collinson, L, Peddie, C, Ali, K, Ghazaly, E, Rajeeve, V, Trichas, G, Srinivas, S, Chaussade, C, Salamon, RS, Backer, JM, Scudamore, CL, Whitehead, MA, Keaney, EP, Murphy, LO, Semple, RK, Payrastre, B, Tooze, SA, Vanhaesebroeck, B
Format:	Journal article
Language:	English
Published:	Springer Nature 2017

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

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