TCR signal strength and T cell development

Thymocyte selection involves the positive and negative selection of the repertoire of T cell receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of the ability to recognize any invading pathogen. The signal transduced through the TCR is translated into a number...

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Bibliographic Details
Main Authors: Gascoigne, N, Rybakin, V, Acuto, O, Brzostek, J
Format: Journal article
Language:English
Published: Annual Reviews 2016