X-linked immunodeficient mice with no functional Bruton's tyrosine kinase are protected from sepsis-induced multiple organ failure

We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymi...

Popoln opis

Bibliografske podrobnosti
Main Authors: O'Riordan, CE, Purvis, GSD, Collotta, D, Krieg, N, Wissuwa, B, Sheikh, MH, Ferreira Alves, G, Mohammad, S, Callender, LA, Coldewey, SM, Collino, M, Greaves, DR, Thiemermann, C
Format: Journal article
Jezik:English
Izdano: Frontiers Media 2020