X-linked immunodeficient mice with no functional Bruton's tyrosine kinase are protected from sepsis-induced multiple organ failure
We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymi...
Príomhchruthaitheoirí: | , , , , , , , , , , , , |
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Formáid: | Journal article |
Teanga: | English |
Foilsithe / Cruthaithe: |
Frontiers Media
2020
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