X-linked immunodeficient mice with no functional Bruton's tyrosine kinase are protected from sepsis-induced multiple organ failure

We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymi...

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Príomhchruthaitheoirí: O'Riordan, CE, Purvis, GSD, Collotta, D, Krieg, N, Wissuwa, B, Sheikh, MH, Ferreira Alves, G, Mohammad, S, Callender, LA, Coldewey, SM, Collino, M, Greaves, DR, Thiemermann, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Frontiers Media 2020