Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.

Effects of the alpha 2-adrenergic agonist clonidine on insulin release, membrane potential, and cytoplasmic free Ca2+ concentration ([Ca2+]i) were investigated using pancreatic beta-cells isolated from obese hyperglycemic mice. Addition of 2 microM clonidine promptly inhibited glucose-stimulated ins...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Nilsson, T, Arkhammar, P, Rorsman, P, Berggren, P
Format: Journal article
Język:English
Wydane: 1988