Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Beta-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall biogenesis. Pathogenic bacteria have evolved efficient antibiotic resistance mechanisms that, in Gram-positive bacteria, include mutations to PBP...

Full description

Bibliographic Details
Main Authors:	Macheboeuf, P, Fischer, D, Brown, T, Zervosen, A, Luxen, A, Joris, B, Dessen, A, Schofield, C
Format:	Journal article
Language:	English
Published:	2007

Similar Items

MEDI 327-Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins
by: Jr, B, et al.
Published: (2008)

Structural basis for the interaction of lactivicins with serine beta-lactamases.
by: Brown, T, et al.
Published: (2010)

Structure guided development of potent reversibly binding penicillin binding protein inhibitors.
by: Woon, E, et al.
Published: (2011)

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.
by: Samo Turk, et al.
Published: (2011-01-01)

Synthesis of an enantiopure thioester as key substrate for screening the sensitivity of penicillin binding proteins to inhibitors
by: Justine F. Simon, et al.
Published: (2016-08-01)

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases.
by: Inglis, SR, et al.
Published: (2012)

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases
by: Inglis, SR, et al.
Published: (2011)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
by: Jürgen Brem, et al.
Published: (2016-08-01)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
by: Brem, J, et al.
Published: (2016)

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.
by: Calvopiña, K, et al.
Published: (2016)

Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6
by: Mohd Zulkifli Salleh, et al.
Published: (2022-07-01)

Binding of (5S)-penicilloic acid to penicillin binding protein 3.
by: van Berkel, S, et al.
Published: (2013)

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).
by: Contreras-Martel, C, et al.
Published: (2011)

Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli.
by: Eric Sauvage, et al.
Published: (2014-01-01)

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
by: Inglis, SR, et al.
Published: (2009)

Proteins of the penicillin biosynthesis pathway.
by: Schofield, C, et al.
Published: (1997)

Proteomics and Docking Study Targeting Penicillin-Binding Protein and Penicillin-Binding Protein2a of Methicillin-Resistant Strain SO-1977 Isolated from Sudan
by: Sofia B Mohamed, et al.
Published: (2019-07-01)

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4.
by: Marcelo Hill, et al.
Published: (2011-01-01)

Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation
by: Lu, Z, et al.
Published: (2020)

Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5
by: Yamanappa Hunashal, et al.
Published: (2023-07-01)

High-throughput crystallography reveals boron-containing inhibitors of a penicillin-binding protein with di- and tricovalent binding modes
by: Newman, H, et al.
Published: (2021)

Synthesis of unnatural substrates as mechanistic probes of the penicillin biosynthetic pathway.
by: Baldwin, J, et al.
Published: (1999)

Penicillin-binding protein genotyping of penicillin-nonsusceptible Streptococcus pneumoniae isolates from the nasopharynx of healthy preschool children
by: Kielbik Karolina, et al.
Published: (2023-06-01)

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
by: Tamara Basta, et al.
Published: (2012-01-01)

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
by: Bertrand Beckert, et al.
Published: (2021-07-01)

The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities
by: Sarah Bonhomme, et al.
Published: (2021-05-01)

Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm
by: Gaurav Kumar, et al.
Published: (2022-02-01)

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.
by: Vijay Kumar, et al.
Published: (2021-01-01)

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3
by: Vijay Kumar, et al.
Published: (2021-01-01)

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials
by: Eric Sauvage, et al.
Published: (2016-02-01)

Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.
by: Daniil M Prigozhin, et al.
Published: (2014-01-01)

High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.
by: Alena Fedarovich, et al.
Published: (2012-01-01)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
by: Conejo-Garcia, A, et al.
Published: (2010)

Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
by: Ren, J, et al.
Published: (2016)

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles
by: Diogo Henrique Kita, et al.
Published: (2021-01-01)

Evolution of Ceftriaxone Resistance of Penicillin-Binding Proteins 2 Revealed by Molecular Modeling
by: Alexandra V. Krivitskaya, et al.
Published: (2022-12-01)

Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins
by: Víctor M Hernández-Rocamora, et al.
Published: (2021-02-01)

Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei.
by: Chantratita, N, et al.
Published: (2011)

Inhibition of penicillin formation by amino acid analogs /
by: Demain, A. L. (Arnold L.), 1927-

Unipolar Peptidoglycan Synthesis in the <i>Rhizobiales</i> Requires an Essential Class A Penicillin-Binding Protein
by: Michelle A. Williams, et al.
Published: (2021-10-01)