Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Beta-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall biogenesis. Pathogenic bacteria have evolved efficient antibiotic resistance mechanisms that, in Gram-positive bacteria, include mutations to PBP...

Bibliografske podrobnosti
Main Authors:	Macheboeuf, P, Fischer, D, Brown, T, Zervosen, A, Luxen, A, Joris, B, Dessen, A, Schofield, C
Format:	Journal article
Jezik:	English
Izdano:	2007

Podobne knjige/članki

MEDI 327-Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins
od: Jr, B, et al.
Izdano: (2008)

Structural basis for the interaction of lactivicins with serine beta-lactamases.
od: Brown, T, et al.
Izdano: (2010)

Structure guided development of potent reversibly binding penicillin binding protein inhibitors.
od: Woon, E, et al.
Izdano: (2011)

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.
od: Samo Turk, et al.
Izdano: (2011-01-01)

Synthesis of an enantiopure thioester as key substrate for screening the sensitivity of penicillin binding proteins to inhibitors
od: Justine F. Simon, et al.
Izdano: (2016-08-01)

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases
od: Inglis, SR, et al.
Izdano: (2011)

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases.
od: Inglis, SR, et al.
Izdano: (2012)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
od: Jürgen Brem, et al.
Izdano: (2016-08-01)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
od: Brem, J, et al.
Izdano: (2016)

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.
od: Calvopiña, K, et al.
Izdano: (2016)

Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6
od: Mohd Zulkifli Salleh, et al.
Izdano: (2022-07-01)

Binding of (5S)-penicilloic acid to penicillin binding protein 3.
od: van Berkel, S, et al.
Izdano: (2013)

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).
od: Contreras-Martel, C, et al.
Izdano: (2011)

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
od: Inglis, SR, et al.
Izdano: (2009)

Proteins of the penicillin biosynthesis pathway.
od: Schofield, C, et al.
Izdano: (1997)

Proteomics and Docking Study Targeting Penicillin-Binding Protein and Penicillin-Binding Protein2a of Methicillin-Resistant Strain SO-1977 Isolated from Sudan
od: Sofia B Mohamed, et al.
Izdano: (2019-07-01)

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4.
od: Marcelo Hill, et al.
Izdano: (2011-01-01)

Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation
od: Lu, Z, et al.
Izdano: (2020)

Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5
od: Yamanappa Hunashal, et al.
Izdano: (2023-07-01)

High-throughput crystallography reveals boron-containing inhibitors of a penicillin-binding protein with di- and tricovalent binding modes
od: Newman, H, et al.
Izdano: (2021)

Penicillin-binding protein genotyping of penicillin-nonsusceptible Streptococcus pneumoniae isolates from the nasopharynx of healthy preschool children
od: Kielbik Karolina, et al.
Izdano: (2023-06-01)

Synthesis of unnatural substrates as mechanistic probes of the penicillin biosynthetic pathway.
od: Baldwin, J, et al.
Izdano: (1999)

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
od: Tamara Basta, et al.
Izdano: (2012-01-01)

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
od: Bertrand Beckert, et al.
Izdano: (2021-07-01)

Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s)
od: Grabrijan Katarina, et al.
Izdano: (2024-09-01)

Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm
od: Gaurav Kumar, et al.
Izdano: (2022-02-01)

The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities
od: Sarah Bonhomme, et al.
Izdano: (2021-05-01)

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.
od: Vijay Kumar, et al.
Izdano: (2021-01-01)

Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis
od: Sinethemba Yakobi, et al.
Izdano: (2024-01-01)

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials
od: Eric Sauvage, et al.
Izdano: (2016-02-01)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
od: Conejo-Garcia, A, et al.
Izdano: (2010)

Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.
od: Daniil M Prigozhin, et al.
Izdano: (2014-01-01)

High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.
od: Alena Fedarovich, et al.
Izdano: (2012-01-01)

Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
od: Ren, J, et al.
Izdano: (2016)

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles
od: Diogo Henrique Kita, et al.
Izdano: (2021-01-01)

Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins
od: Víctor M Hernández-Rocamora, et al.
Izdano: (2021-02-01)

An alternative penicillin-binding protein involved in Salmonella relapses following ceftriaxone therapy
od: Sónia Castanheira, et al.
Izdano: (2020-05-01)

Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei.
od: Chantratita, N, et al.
Izdano: (2011)

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats
od: Iga Kucharska, et al.
Izdano: (2022-01-01)

Unipolar Peptidoglycan Synthesis in the <i>Rhizobiales</i> Requires an Essential Class A Penicillin-Binding Protein
od: Michelle A. Williams, et al.
Izdano: (2021-10-01)