Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Beta-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall biogenesis. Pathogenic bacteria have evolved efficient antibiotic resistance mechanisms that, in Gram-positive bacteria, include mutations to PBP...

詳細記述

書誌詳細
主要な著者: Macheboeuf, P, Fischer, D, Brown, T, Zervosen, A, Luxen, A, Joris, B, Dessen, A, Schofield, C
フォーマット: Journal article
言語:English
出版事項: 2007