Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.

Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of...

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Detalles Bibliográficos
Main Authors: Sumara, G, Formentini, I, Collins, S, Sumara, I, Windak, R, Bodenmiller, B, Ramracheya, R, Caille, D, Jiang, H, Platt, K, Meda, P, Aebersold, R, Rorsman, P, Ricci, R
Formato: Journal article
Idioma:English
Publicado: 2009