Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era

Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high <i>Plasmodium falciparum</i> transmission in sub-Saharan Africa. From this we estimate that the malaria-attribu...

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Bibliografiske detaljer
Main Authors: Watson, JA, White, NJ, Dondorp, AM
Format: Journal article
Sprog:English
Udgivet: Cell Press 2021