Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly-Specific, Novel Mouse Model of Altered COMT Activity.
Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex (PFC). The human gene contains a polymorphism (Val(158)Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but findings are mixed. We therefore develop...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2016
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