The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.
We have studied the role of carbonic anhydrase 9 (CA9), a cancer-associated extracellular isoform of the enzyme carbonic anhydrase in multicellular spheroid growths (radius of approximately 300 microm) of human colon carcinoma HCT116 cells. Spheroids were transfected with CA9 (or empty vector) and i...
Main Authors: | Swietach, P, Patiar, S, Supuran, C, Harris, A, Vaughan-Jones, R |
---|---|
פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2009
|
פריטים דומים
-
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
מאת: Swietach, P, et al.
יצא לאור: (2008) -
Regulation of tumor pH and the role of carbonic anhydrase 9.
מאת: Swietach, P, et al.
יצא לאור: (2007) -
Carbonic anhydrase IX unifies spatial pH(i) regulation in large cell-clusters
מאת: Swietach, P, et al.
יצא לאור: (2007) -
Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.
מאת: Swietach, P, et al.
יצא לאור: (2012) -
Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure
מאת: Hulikova, A, et al.
יצא לאור: (2014)