Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols

The TAR DNA Binding Protein 43 (TDP-43) has been implicated in the pathogenesis of human neurodegenerative diseases and exhibits hallmark neuropathology in amyotrophic lateral sclerosis (ALS). Here, we explore its tractability as a plasma biomarker of disease and describe its localization and possib...

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Main Authors:	Luthi-Carter, R, Cappelli, S, Le Roux-Bourdieu, M, Tentillier, N, Quinn, JP, Petrozziello, T, Gopalakrishnan, L, Sethi, P, Choudhary, H, Bartolini, G, Gebara, E, Stuani, C, Font, L, An, J, Ortega, V, Sage, J, Kosa, E, Trombetta, BA, Simeone, R, Seredenina, T, Afroz, T, Berry, JD, Arnold, SE, Carlyle, BC
Format:	Journal article
Language:	English
Published:	Nature Research 2024

Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols

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