Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Parkinson’s disease (PD) is characterized by a progressive deterioration of motor and cognitive functions. Although death of dopamine neurons is the hallmark pathology of PD, this is a late-stage disease process preceded by neuronal dysfunction. Here we describe early physiological perturbations in...

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Bibliographische Detailangaben
Hauptverfasser:	Beccano-Kelly, DA, Cherubini, M, Mousba, Y, Cramb, KML, Giussani, S, Caiazza, MC, Rai, P, Vingill, S, Bengoa-Vergniory, N, Ng, B, Corda, G, Banerjee, A, Vowles, J, Cowley, S, Wade-Martins, R
Format:	Journal article
Sprache:	English
Veröffentlicht:	Cell Press 2023

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